pH Measurement & Dissolved Oxygen Measurement in Stainless Steel Bioreactors
Accurately measure pH levels & dissolved oxygen concentrations in pharmaceutical manufacturing
Reliability After Steam-in-Place (SIP) & Clean-In-Place (CIP)
pH and dissolved oxygen are critical process parameters in pharmaceutical manufacturing that must be accurately monitored and controlled to produce high-quality biological drugs. Most bioreactors utilize two sensors for each measurement for redundancy and accuracy. In stainless steel bioreactors, SIP and CIP cycles can degrade sensors over time. The Rosemount™ Hx338+ Steam Sterilizable and Autoclavable pH Sensor is constructed to withstand the high temperatures of SIP and harsh chemicals of CIP. Furthermore, it provides a pressurized reference electrode which works to maintain a drift-free pH signal and fights poisoning ions. Likewise, the Rosemount Hx438 Steam Sterilizable Dissolved Oxygen Sensor is an amperometric sensor designed to withstand repeated steam sterilization cycles.
Click to continue reading Reliability After Steam-in-Place (SIP) & Clean-In-Place (CIP)
Product Solutions
The Rosemount Hx338+ Steam Sterilizable & Autoclavable pH Sensor provides the biotechnology and pharmaceutical industries with a unique pre-pressurized pH reference technology. The pre-pressurized reference stops contamination between batches by not allowing the process to leak into the pH sensor. The pH reference also features a triple barrier junction which works to maintain a drift-free pH signal and fight poisoning ions (i.e., sulfides, proteins, or sugars), even after numerous sterilization cycles.
- Provides protection against batch cross-contamination with a pre-pressurized reference
- Measures accurately after many SIP cycles at 286°F (140°C)
- Installs easily with quick disconnects from cable-to-sensor
Measurement Range
pH sensor: 0-14 pH
Operating Temperature
32 - 284 °F (0 - 140 °C)
Operating Pressure
0-87 psig (0-6 Bar)
The Rosemount Hx438 Steam Sterilizable Dissolved Oxygen (DO) Sensor is a membrane-covered amperometric sensor designed to meet the demanding requirements of the biotechnology, pharmaceutical, and food and beverage industries. The dissolved oxygen sensor provides a drift-free signal and maintains its calibration value for up to 50 steam sterilization cycles.
- Tolerates repeated steam sterilization
- Sensor response practically independent of flow
- Fast response time
Measurement Range
0 to 20 ppm, 0 to 250 % saturation, depending on instrument
Operating Temperature
32 to 266 °F (0 to 130 °C)
Maximum Pressure
43 psig (400 kPa abs, 4 bar)
The Rosemount 1056 Transmitter offers single or dual sensor input with an unrestricted choice of dual measurements, reducing the cost per loop and saving panel space. This multi-parameter liquid analysis transmitter offers a wide range of measurement choices, including differential conductivity, dual oxygen and many other combinations supporting most industrial, commercial and municipal applications. The modular design of the transmitter allows signal input boards to be field replaced making configuration changes easy.
- Fast and easy installation using Quick Start programming, auto-recognition of sensor boards and modular design
- Large customizable display provides at-a-glance view of pertinent information
- Visibility of process parameters by utilizing HART® or Profibus DP digital communications
Enclosure Rating
Polycarbonate. Type 4X, IP65.
Certifications/Approvals
FM/CSA/UL (See Product Data Sheet for complete list of certifications.)
Dimensions
Overall 155 x 155 x 131mm (6.10 x 6.10 x 5.15 in.). Cutout: 1/2 DIN 139mm x 139mm (5.45 x 5.45 in.)
