Clean room HVAC systems in life sciences and other industries are inherently energy-intensive due to the high air exchange rates, filtration systems, and stringent climate controls required to maintain their pristine conditions. This makes the optimization of thermal energy management even more critical. By continuously monitoring and adjusting the HVAC system, facilities can enhance energy efficiency, reduce operational costs, and maintain regulatory compliance. Effective thermal energy management ensures a consistent, contamination-free environment, essential for high-quality life sciences outcomes while mitigating the significant energy demands of these facilities.