pH Measurement in Batch & Continuous Liquid Chromatography for Biopharmaceutical Needs
Tighter pH Control of Mobile Phase in Chromatographic Separations
Accurate pH Measurement after SIP & CIP cycles
Continuous Liquid Chromatography Systems are designed for continuous separation and purification of bio-engineered products like proteins, antibodies, DNA and viruses. pH measurement plays an important role in downstream processing of these products. Controlling the pH of the mobile phase of the chromatograph to the value determined during method development will change the ionization state of the analyte, strengthening the interaction between the analyte and stationary phase and leading to enhanced retention and selectivity. Extremes in pH of the mobile phase can cause degradation of the stationary phase and chromatograph column. The system’s wetted components must be able to withstand clean-in-place (CIP) and steam-in-place (SIP) cycles, which can stress a pH sensor with high heat and caustic. The Rosemount Hx338+ pH Sensor features a pressurized reference junction that works to maintain a drift-free pH signal and fight poisoning ions, even after numerous sterilization cycles.
Click to continue reading Accurate pH Measurement after SIP & CIP cycles
Product Solutions
The Rosemount Hx338+ Steam Sterilizable & Autoclavable pH Sensor provides the biotechnology and pharmaceutical industries with a unique pre-pressurized pH reference technology. The pre-pressurized reference stops contamination between batches by not allowing the process to leak into the pH sensor. The pH reference also features a triple barrier junction which works to maintain a drift-free pH signal and fight poisoning ions (i.e., sulfides, proteins, or sugars), even after numerous sterilization cycles.
- Provides protection against batch cross-contamination with a pre-pressurized reference
- Measures accurately after many SIP cycles at 286°F (140°C)
- Installs easily with quick disconnects from cable-to-sensor
Measurement Range
pH sensor: 0-14 pH
Operating Temperature
32 - 284 °F (0 - 140 °C)
Operating Pressure
0-87 psig (0-6 Bar)
The Rosemount 1058 Dual Channel Transmitter provides confident liquid analysis measurement in a wide range of industrial, municipal and commercial applications. It is a 4-wire powered device that provides multi-parameter liquid analysis for digital and analog sensors, including inputs from pH/ORP sensors, ISE, flow, current, conductivity sensors (contacting and toroidal), turbidity sensors and amperometric sensors (dissolved oxygen, chlorine and ozone).
- Supports continuous measurement of liquid analysis inputs from one or two sensors.
- Each sensor channel is independently configurable to support a wide selection of digital or analog liquid analysis sensors including pH sensors, ORP sensors, conductivity sensors, dissolved oxygen sensors, chlorine senors, turbidity sensors and more.
- IP66 / Type 4X rated engineered polymer enclosure with universal mounting options provides confident and easy installation indoors or outdoors.
Enclosure Rating
Type 4X, IP66
Dimensions
Overall 160 x 157 x 140 mm (6.3 x 6.2 x 5.5 in); Cutout 138.4 x 138.4 mm (5.45 x 5.45 in)
Weight
3 lb (1.5 kg)
The Rosemount 1056 Transmitter offers single or dual sensor input with an unrestricted choice of dual measurements, reducing the cost per loop and saving panel space. This multi-parameter liquid analysis transmitter offers a wide range of measurement choices, including differential conductivity, dual oxygen and many other combinations supporting most industrial, commercial and municipal applications. The modular design of the transmitter allows signal input boards to be field replaced making configuration changes easy.
- Fast and easy installation using Quick Start programming, auto-recognition of sensor boards and modular design
- Large customizable display provides at-a-glance view of pertinent information
- Visibility of process parameters by utilizing HART® or Profibus DP digital communications
Enclosure Rating
Polycarbonate. Type 4X, IP65.
Certifications/Approvals
FM/CSA/UL (See Product Data Sheet for complete list of certifications.)
Dimensions
Overall 155 x 155 x 131mm (6.10 x 6.10 x 5.15 in.). Cutout: 1/2 DIN 139mm x 139mm (5.45 x 5.45 in.)
The Rosemount 1066 Single Channel Transmitter supports continuous measurement of one liquid analytical input - pH sensor, conductivity sensor, chlorine sensor, dissolved oxygen sensor or ozone sensor. The design supports easy internal access and wiring connections. The large display gives excellent visibility for live measurements and displayed parameters. Conveniently, live process values are always displayed during programming and calibration routines.
- Fast and easy installation using Quick Start programming
- Intrinsically Safe FM, CSA, and ATEX/IECEx Hazardous Location Approvals
- Visibility of process parameters by utilizing HART® or FOUNDATION™ Fieldbus digital communications
Power Supply
Supply voltage at the transmitter terminals should be at least 12.7Vdc. Power supply voltage should cover the voltage drop on the cable plus the external load resistor required for HART® communications (250 Ω)
Weight
R2 lbs/3 lbs (1 kg/1.5 kg)
Communication Protocol
HART™ Communications & diagnostics: PV, SV, TV, and 4V assignable, temperature
